Clinical

Lymphoepithelioma-Like Carcinoma of the Uterine Cervix – Reporting Three Rare Clinical Cases with Lymph Node Metastasis

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We present three cases of LELC with lymph node metastasis and a follow- up of the patients. The diagnosis was confirmed histologically. All three cases have been examined Immunohistochemically for assessment of the viral status for both EBV and HPV. Two of them died from the cervical cancer and one is still alive without evidence of recurrence. The results of the immunohistochemical study showed that two of them were negative for both viruses and one was positive only for EBV. Our data shows that the immunohistochemical results for the viral status cannot be used as a predictive factor as opposed to the lymph node status and lymphovascular space invasion (LVSI).

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Ophthalmology case reports

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Ophthalmology case reports are defined as the case reports which deal with the diseases of the eye. Ophthalmology is the branch of medical science which studies the various aspects of eye. Case reports cover the details of disease and treatment of the eye or the related organ.

Read more: https://www.scitechnol.com/clinical-images-case-reports.php

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Legionnaires Disease

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Legionnaires disease, also called legionellosis, is caused by the bacteria Legionella pneumophila and related species. These organisms have been found in water delivery systems. The infection can be caught by inhaling mists from water contaminated with the germs. Outbreaks have been traced to contaminated whirlpool spas, humidifiers, and air conditioning cooling towers and have occurred in hospitals, hotels, and cruise ships. The incubation period for legionnaires disease is 2 to 10 days.

The disease and the organism that causes legionnaires disease were identified and got their names from the first known outbreak, at an American Legion convention held at a Philadelphia, PA, hotel in 1976.

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Hantavirus Pulmonary Syndrome

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Hantavirus pulmonary syndrome (HPS) was first identified in 1993 when an outbreak of this infectious lung disease took place in the southwestern United States. The viruses that cause HPS come from a group of organisms known as hantaviruses. These germs are carried by particular kinds of mice. People get the infection by direct contact with infected rodents or their droppings, urine, or saliva or breathing in air contaminated with the virus. On rare occasions, the infection is passed to humans by a mouse bite. There is no evidence that it can be spread from person to person. The incubation period (the time after contact with an infected mouse to the beginning of symptoms) may be 1 to 6 weeks, though that period has not been established definitively.

The majority of cases of HPS occur during the spring and summer, mostly in rural areas. Although it is a relatively uncommon infection, it can be deadly.

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Mcl-1 is a Gate Keeper Regulating Cell Death in Cancer Cells

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Selectively inducing cancer cells to death is the goal of cancer therapy. The discovery of B-cell lymphoma 2 (Bcl-2) family members regulating apoptotic cell death of cancer cells revealed new targets for cancer therapy. Bcl-2 family members can be classified into pro-apoptotic members and anti-apoptotic members among which myeloid cell leukemia 1 (Mcl-1) plays unique roles in regulating cell death and survival in cancer cells. Mcl-1 has a short half-life due to its degradation by multiple E3 ubiquitin-ligases. Under hypoxic conditions, Mcl-1 is up-regulated by activation of growth factor receptor, EGFR promoting cell survival whereas, prolonged/severe hypoxia leads to deactivation of EGFR and Mcl-1 degradation by E3 ubiquitin -ligase FBW7 contributing to cell death. Furthermore, cancer cells upregulated Mcl-1 contributing resistance to chemotherapeutic treatment such as by inhibitors of other antiapoptotic Bcl-2 members Bcl-2, Bcl-xL and Bcl-w. Therefore, Mcl- 1 might be the key player in pro-survival Bcl-2 family members in regulating cancer cell death. This encourages the on-going active development of Mcl-1 specific inhibitors for cancer treatment.

Read more: https://www.scitechnol.com/clinical-experimental-oncology.php

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Carcinogenesis

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Carcinogenesis, also called oncogenesis or tumorigenesis, is the development of a cancer, whereby normal cells are converted into cancer cells. The development is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological manner that happens in nearly all tissues and below a variety of circumstances. Normally stability among between proliferation and programmed cell death, within the form of apoptosis, is maintained to ensure the integrity of tissues and organs.To Know more visit  the link

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Brain inflammation can lead to the increased thinking of suicidality

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Patients with major depressive disorder (MDD) have increased brain levels of a marker of microglial activation, a sign of inflammation, according to a new study. Scientists have found that the increase in the inflammatory marker was present specifically in patients with MDD who were experiencing suicidal thoughts, pinning the role of inflammation to suicidality rather than a diagnosis of MDD itself.

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