Feasibility of Single Tumorspot Treatment in Peritoneal Carcinomatosis via Close Range Doxorubicin Impaction in Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC)
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a well-established, yet not fully evaluated new treatment approach for peritoneal carcinomatosis with the aim at enabling localized application of chemo aerosol within the abdominal cavity. Distribution inhomogeneity in PIPAC has been previously indicated in prior experiments. This study was conducted to investigate whether this finding can be used to achieve localized high drug concentrations into micro metastasis. PIPAC construct was built using a hermetic container system which mimics the abdominal cavity. Fresh parietal peritoneum portions from post-mortem swine were cut into samples and placed vertically in the center of a box. The Micropump© (MIP) was introduced via trocar at the side of the box and located at 1cm from the samples to enable close range impaction of the aerosolized doxorubicin with the samples. Doxorubicin penetration depth was radially measured by fluorescence microscopy from the center of targets to the outer rim. Tissue doxorubicin penetration in the tissue was lower towards the outer rim and further away from the center of the sprayjet. Maximal penetration of drug was achieved in the midpoint of the sprayjet with 417± 87(SD) µm and a minimal penetration was reached at 3 cm from center with 45 ± 20 (SD) µm….to read more: https://www.scitechnol.com/peer-review/feasibility-of-single-tumorspot-treatment-in-peritoneal-carcinomatosis-via-close-range-doxorubicin-impaction-in-pressurized-intrap-sG1B.php?article_id=6082
Tetraspnin CD151 is involved in proliferation, motility, and invasion. Yet, the role of CD151 in estrogen receptor positive breast cancer is not reported. In the present study, the role of CD151 in survival of ER positive cell line and the underlying molecular partners was reported. CD151 shRNA expression vector was transfected into MCF-7 cells and its efficacy was evaluated by RT-PCR. The capacity of proliferation, migration, and invasion, cell adhesion, angiogenesis of MCF-7 cells was diminished by the knockdown of CD151 via CD151 specific shRNA. It arrested the cell cycle at G2/M phase and induced the apoptosis. The expressions of c-myc, α3β1 integrin, IL-8, Ras, FAK and VEGF were reduced by knockdown of CD151. The results conclude that CD151 gene silencing affects the expression of its network partner’s associate with survival of MCF-7 cells. Therefore, CD151 may be a potential target of luminal and basal subtypes…..to read more: https://www.scitechnol.com/peer-review/knockdown-of-cd151-gene-expression-reduces-survival-of-estrogen-receptor-positive-breast-cancer-cells-mC1L.php?article_id=6081
Systemic sclerosis (also scleroderma) is a chronic, autoimmune rheumatic disease affecting the skin and other organs. The hallmark of the disease is thickening/tightening of the skin and inflammation/scarring of various organs/body parts, leading to involvement of the lungs, kidneys, heart, intestinal system, and other areas. There is no cure for scleroderma but effective treatments for some features of the disease are available. The disease is relatively uncommon. About 75,000–100,000 people in the United States have the disease; most are women between the ages of 30 and 50 years. Twins and family members of those with scleroderma or other autoimmune connective tissue diseases, such as lupus, may have a slightly higher risk of developing scleroderma. Children can also get scleroderma, but the disease is different in children from that in adults. Although the underlying cause is unknown, research is shedding more light on the relationship between genes, the immune system and scleroderma.
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Allergic rhinitis usually presents in early childhood and is caused by an immunoglobulin E (IgE)-mediated reaction to various allergens in the nasal mucosa. Sensitization to outdoor allergens can occur in allergic rhinitis in children older than 2 years; however, sensitization to outdoor allergens is more common in children older than 4-6 years. Clinically significant sensitization to indoor allergens may occur in children younger than 2 years. The most common allergens include dust mites, pet danders, cockroaches, molds, and pollens.
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CT and MRI examinations of patients with peritoneal carcinomatosis were evaluated. CT images were first analysed by two observers who determined a first PCI (PCICT). Then, the two observers reviewed MRI examinations in combination with CT and determined a second PCI (PCICT + MRI). The sensitivity and negative predictive value of the two imaging sets were determined using surgery as a reference standard.
According to some guidelines for the management of gastric cancer, adjuvant chemotherapy is recommended for patients with pT3–4 or node‐positive disease. The aim of this study was to define low‐ and high‐risk groups in terms of survival, and to predict the benefit of adjuvant fluoropyrimidine plus oxaliplatin (F‐OX) chemotherapy.
It’s estimated that more than 15,000 people suffer from spinal cord injury each year in Indonesia, and most of them will die because of the complication. The treatment and rehabilitation for them require lots of fund and in countries like Indonesia will be a huge burden for the family. There is very limited access to a good rehabilitation facilities or appropriate hospital care for spinal cord injuries; this also contributes to a high mortality rate especially after the cervical cord injury. We believe that more than one third of the world population is still facing the same situation like in Indonesia.
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