Pharmaceutical science

Anti-Microbial Activity

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Since last three decades pharma industries have been producing the more number of antibiotics while resistance to these drugs by microorganisms has increased. Actual situation explains is different, industries who producing the antibiotics should rethink in manufacturing the drugs and to design and necessary precautions should follow during production instead adding the preventives and using of natural process may give better results. These therapeutic agents should be used more to relative control Of microbial activity

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Anti-proliferative Activity

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Thin layer Chromatography is used to identify the activity fraction of alcohols like ethanol, methanol, butanol, chloroform, n-hexane while evaluation of anticancer agents in invitro conditions for anti-proliferative activity against Hep-2, MCF-7, and Vero cell lines. Methanol was extracted from aerial parts of the Ononis hirta and from flowers of Inula viscosa

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Bath Salts Difficult To Detect In Biological Samples

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Bath salts were traditionally sold in smoke shops and on the internet. The DEA ban cathinones, it was quickly replaced with new alternatives by the manufacturers and many labs do not test for these drugs. While testing for these components in drug material like pills, powder is relatively easier than detecting them in biological system or evidences.

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Role of Oxidative Stress in Male Fertility and Idiopathic Infertility: Causes and Treatment

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Epidemiological studies regarding male infertility have revealed that more and more infertile men suffer from acute or chronic inflammation of the genitourinary tract, which often occurs without any symptoms. The exact mechanism for unexplained male infertility and its correlation to oxidative stress incidence and/ or the inflammatory reactions within the male genital tract is still controversially unclear till know. Previous studies have shown the presence of cytokines such as tumor necrosis factor-α (TNF-α), a key player in the inflammation process, in the semen of infertile men. However, the mechanism of their effect on human sperm functions is still in need for further under investigations. We expect that, seminal inflammatory cytokine (TNF-α) and its expression regulator, testicular ADAM 17, will be varied, when seminal OS is established, that in turn, will vary cellular integrity and energy status. As conventional treatment of male infertility such as mineral and vitamins supplementation has poor success rates and leaves a lot to be desired, natural antioxidant ingredients are greatly suggested, nowadays, to ameliorate oxidative stress and the inflammatory detrimental effects accompanied to idiopathic male infertility.

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Acyl-Glucuronide and Acyl-Glutathione The Effects of 1-Aminobenzotriazole Inhibition on the Formation of Metabolites in Rat Hepatocytes

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1-Aminobenzotriaole (ABT) is a commonly used non-selective mechanism based human and non-human cytochrome P450 (P450) inactivator. However, the direct effects of ABT mediated P450 inhibition on conjugative metabolism, specifically acyl-glucuronide and acyl-glutathione formation has not been previously investigated. In the present study, we evaluated the in vitro effects of ABT induced inhibition of P450 metabolism on the formation of 1-O-acyl-glucuronides of the carboxylic acid-containing drugs gemfibrozil (GEM), tolmetin (TOL), mefenamic acid (MFA), and diclofenac (DCF), and the S-acyl-glutathione formation of MFA and DCF in rat hepatocytes. In vitro incubations of each carboxylic acid-containing drug (100 μM) separately in rat hepatocytes preincubated (30 min) with ABT (500 μM), resulted in 12.7%, 30%, 37%, and 40% increases in the formation of 1-O-acyl-glucuronides at the 30 min time point for GEM, TOL, MFA, and DCF, respectively.

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Studies show Omega-3 fatty acids can produce same medicinal qualities as Marijuana

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Studies have revealed that the chemical components found in marijuana called Cannabinoids are also produced naturally in our body by omega-3 fatty acids. The cannabinoids present in marijuana is known to have anti-inflammatory properties. A study revealed that omega-3 fatty acid is also converted in cannabinoids with is having anti-inflammatory benefits but much of psychotropic effect.

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Autism Spectrum Disorder

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Autism is a type of disorder. It is also called as autism spectrum disorder, people with this disorder suffer from few neurological malfunctions like repetitive behavior conditions characterized by challenges with social skills, speech and nonverbal communication. Autism is one of the genetic disorder effects the neurological development and they do not have simple moment to take it may happen with the general population too……

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