Pharmaceutical science

Importance of analytical methods to understand the complexity and diversity of protein aggregation

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In this 4 to 6 hours course the attendees will lear, based on biopharmaceutical case studies, about the complexity and diversity of the aggregation of peptide and protein drugs and on strategies to overcome these issues. The workshop will have the following parts: Part 1: Examples of protein aggregation mechanisms Part 2: Available techniques for detection of aggregation and impurities (leachables) and how these methods can be applied. Combining analytical methods to ensure detection of aggregates across a range of particle sizes. New technologies for characterization of aggregates will be presented. Part 3: Strategies for developing stable peptide drug formulations. High-throughput analysis (HTA) and high-throughput formulation (HTF) platforms will be presented. Using case studies, potential causes of aggregation and prevention strategies will be discussed.

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Submit manuscript at editor.jdtba@scitechnol.com

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Chemical Toxicology and Pharmacology

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Chemical Toxicology and Pharmacology together is a growing field of science reflecting the studies of toxic and pharmacological effects of drugs on Environment, Human beings and Animals. Thus, living beings are more affects pertained to the action of chemicals, drugs, toxicologic/pathologic lesions.

Read related article @ Forensic Toxicology & Pharmacology

For more information click https://www.scitechnol.com/forensic-toxicology-pharmacology.php

Release Kinetics of Cellulosic Nano particulate Formulation for Oral Administration of an Antiviral Drug: Effect of Process and Formulation variables

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Recently, researchers have increasing interest in cellulosic polymers for optimizing the efficiency of existing drugs utilizing better-designed drug delivery systems. In the present research nanoparticles were prepared using cellulose esters to obtain a drug product with a good oral bioavailability and biological half-life. Acyclovir (ACY) was formulated by combining the modified solvent evaporation/extraction technique, sonicator and high pressure homogenization approaches. Various formulation parameters such as sonication-time, concentration of cellulose esters and surfactants were studied. Nanoparticles were obtained with enhanced encapsulation efficiency, negatively charged, defined shape, size and with homogeneous size distribution.

To read more: https://www.scitechnol.com/release-kinetics-of-cellulosic-nano-particulate-formulation-for-oral-administration-of-an-antiviral-drug-effect-of-process-and-formulation-variables-mCF6.php?article_id=2480

To know more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

Submit Manuscript: editor.jpsed@scitechnol.com

Quercetin Ameliorates Chronic Type 2 Diabetes Induced by Long-Term High-Fat, High-Sucrose Diet via Modifying Expression of Genes Involved in Energy Homeostasis and Inflammation

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Type 2 diabetes (T2D) is a metabolic health disorder that induces aberrant gene expression thought to maintain the disease persistent in absence of the initial triggers. The current T2D therapeutics pose adverse side effects, some of which are hypoglycemia and weight gain-exacerbated insulin resistance. We studied whether regulation of adiponectin (ADIPOQ), glucose transporter -2 (GLUT-2) and C-reactive protein (CRP) genes by quercetin would completely cure T2D induced by longterm consumption of high-fat, high-sucrose diet (HFHSD) in male Wistar rats. Thus, sixty male Wistar rats were randomized into three experimental groups (n=20): normal control (C) fed chow diet,diabetic control (D) fed the HFHSD and diabetic quercetin-treated(Q) fed the HFHSD and gavaged with quercetin at 80 mg.kg-1bw.day-1 starting on Day 0 through Day 120. On Days 0 and 120, rats were euthanized and blood samples were used to study the ensuinghyperglycemia, hyperinsulinemia, insulin resistance and plasma CRP concentration.

To read more: https://www.scitechnol.com/peer-review/quercetin-ameliorates-chronic-type-2-diabetes-induced-by-longterm-highfat-highsucrose-diet-via-modifying-expression-of-genes-invol-Ipls.php?article_id=5587

To know more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

Submit Manuscript: editor.jpsed@scitechnol.com

Precise analysis of elements in silica powders by LA-ICP-MS

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Silica is important component of many heterogeneous catalysts. Catalysis affects ~90% of all chemical products. For elemental analysis by AA or ICP these silica-based catalysts are dissolved by HF and other acids. HF is exceptionally dangerous because of its ability to diffuse through the skin where the fluoride ion binds calcium with subsequent disruption of electrical activity. Therefore, it is desirable to minimize its use to reduce risk and eliminate a lengthy and tedious dissolution process. We speculated that coupling laser ablation (LA) to an ICP-MS could fulfill this desire. However, LA cannot be used for powder samples and LA-ICP-MS is known to be much less accurate than liquid phase measurements, owing to inhomogeneous ablated particle size and inadequate analysis parameters. Here, we report the development of a LA-ICP-MS method for accurately analyzing powdered silica supported catalysts. We melt the powders with a mixture of Li2B4O7 – LiBO2 into a homogeneous solid bead, vaporize the surface with a laser, and then apply a small cyclone before the ICP. Moreover, we optimized the analysis conditions by using statistical experimental design of 11 parameters.

Read more at http://bit.ly/2ymFWNG

Visit Journal at http://bit.ly/2wxjRzn

Submit manuscript at editor.jdtba@scitechnol.com

Release Kinetics of Cellulosic Nano particulate Formulation forOral Administration of anAntiviral Drug: Effect of Process and Formulation variables

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Recently, researchers have increasing interest in cellulosic polymers for optimizing the efficiency of existing drugs utilizing better-designed drug delivery systems. In the present research nanoparticles were prepared using cellulose esters to obtain a drug product with a good oral bioavailability and biological half-life. Acyclovir (ACY) was formulated by combining the modified solvent evaporation/extraction technique, sonicator and high pressure homogenization approaches. Various formulation parameters such as sonication-time, concentration of cellulose esters and surfactants were studied. Nanoparticles were obtained with enhanced encapsulation efficiency, negatively charged, defined shape, size and with homogeneous size distribution.

To read more: https://www.scitechnol.com/release-kinetics-of-cellulosic-nano-particulate-formulation-for-oral-administration-of-an-antiviral-drug-effect-of-process-and-formulation-variables-mCF6.php?article_id=2480

To know more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

Contact us by E-mail: editor.jpsed@scitechnol.com

First Dose Combination Studies of Anti-Tuberculosis Drugs With Piperic Acid

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The combinatorial effect of piperic acid with various anti-tuberculosis (anti-TB) drugs was evaluated in vitro against Mycobacterium tuberculosis. The present study has demonstrated for the first time that a combination of piperic acid with rifampicin imparts a synergic effect against M. tuberculosis

To read more: https://www.scitechnol.com/first-dose-combination-studies-of-antituberculosis-drugs-with-piperic-acid-uDeP.php?article_id=2478

To know more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

Contact us by E-mail: editor.jpsed@scitechnol.com