Pharmaceutical science

Emerging Drugs

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Emerging Drugs are newly formed drugs use for the disease treatment having psychological effect after introducing in the body. Drug therapy also referred to as pharmacotherapy, is a common terminology often used in the field of biomedical science as well as epidemiology. It is a well acknowledged fact that the efficacy of the prescribed drug relies on the specific receptors and the interaction between the drug and its specific receptor encourages the healthy functioning of the cells. Drug therapy is the treatment of disease through the administration of drugs. As such, it is considered part of the larger category of therapy. Pharmacists are experts in pharmacotherapy and are responsible for ensuring the safe, appropriate, and economical use of medicines. The mode of drug intake varies from one person to the other and also depends on the condition of the patient undergoing the therapy. Although, the employed therapies free the patient from the ailment, occurrence of side effects cannot be ruled out. But these side effects are transitory and will last for a short period of time. Hence in most cases, the side effects will not last beyond the course of treatment…to read more:  https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

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Medicinal Chemistry

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Medicinal chemistry is the chemistry discipline concerned with the design, development and synthesis of pharmaceutical drugs. It combines expertise from chemistry and pharmacology to identify, develop and synthesize chemical agents that have a therapeutic use and to evaluate the properties of existing drugs. Medicinal Organic chemistry deals with the structure, properties, and reactions of Pharmacoanalysis, the chemical analysis and organic compounds. Medicinal Organic Chemistry Letters will be merged with Chemistry section. Medicinal chemical research is disclosure of novel experimental achievements. Medicinal chemical research feats in many facets of drug design, drug discovery and the elucidation of mechanisms of action of biologically active compounds. Applied Medicinal Chemistry in its most common practice focusing on small organic molecules. Applied Medicinal Chemistry encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Medical biochemistry is a field that studies different types of molecules in hopes of bettering technology and medicine….to read more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

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A Case of Ethanol Intoxication in an Alcoholic Abuser under LongTerm Treatment with GHB

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Gamma-hydroxybutyrate (GHB) is a naturally occurring short-chained fatty acid produced endogenously within the mammalian brain. This drug has found legal uses as an anesthetic agent and in the treatment of narcolepsy. GHB has been used for alcohol withdrawal syndrome and long term treatment of alcohol addiction. In Italy this drug can be used for the treatment of alcoholism under the supervision of a physician. Research into the nature of these interactions is incomplete and often contradictory. There is evidence that the mechanism in which the 2 drugs interact may be synergistic in nature, such that, when low doses of GHB and alcohol are combined, the resulting effects of the drug combination are markedly greater than the predicted effects based upon each drug administered alone.a patient under long-term treatment with GHB for alcohol addiction who was found dead for choking. The toxicological analysis showed a blood alcohol concentration of 2.6 g/L indicating a condition of acute intoxication and GHB concentration in peripheral blood as 9.85 μg/ml. We show autopsy and toxicological data and briefly discuss the possible pathophysiological mechanisms underlying the interaction.

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Beware of 25C-NBOMe: An Nbenzyl substituted Phenethylamine

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Substituted phenethylamines and their derivatives are designer drugs that hold a significantposition in the current drug abuse market 2- (4 – chloro – 2,5 – dimethoxyphenyl) – N – (2- methoxybenzyl) ethanamine (25C-NBOMe) is the N- benzyl derivative of the psychedelicchloro – substituted dimethoxy – phenethylamine that is highly potent and invaded recently inthe “drug arena”. Public should remain vigilant as various new substituted phenethylamines continuously appear. Clinicians and medical doctors should strongly discourage the purchase and use of psychedelic drugs and inform the public of all thesevere consequences associated with such a use. The development of proper routine analytical methods for the determination of phenethylamine derivatives and their metabolites in biological fluids is needed for proper toxicological investigation of forensic and clinical cases.

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Pharmaceutical Analysis

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Pharmaceutical Analysis is also known as Quantitative Pharmaceutical Chemistry Biology Essay. It determines the quality of drug products via analytical chemistry. This course will introduce areas such as method validation, handling raw materials and finished products, documentations, inspections that impact the development of pharmaceutical products. Pharmaceutical Analysis is an analytical method which gives the information about the purity and safety of the products. Briefly it can be described as it identifies, determines, quantifies, purifies and separates the active compound from the mixture. Pharmaceutical analysis could also be outlined as a method or a sequence of processes to spot and/or quantify a substance or drug, the elements of a pharmaceutical resolution or mixture or the determination of the structures of chemical compounds utilized in the formulation of pharmaceutical product. Pharmaceutical analysis is often classified in numerous ways. Proximate Analysis: It determines the number of every component during a sample with no concern on the particular compounds gift. Partial Analysis: It deals with the determination of selected constituents within the sample. Trace Constituent Analysis: A specialized instance of partial analysis within which we have a tendency to be upset concerning the determination of nominative elements gift in terribly minute amount. Complete Analysis: It determines the proportion of every part of the sample.…to read more: https://www.scitechnol.com/scholarly/pharmaceutical-analysis-journals-articles-ppts-list.php

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Drug Intoxication

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Toxicology is the study of the adverse effects of drugs and chemicals on biological systems. Drug intoxication is the physical state in which impairment is caused after exposing to a drug. Drug intoxication can have mental effects also. Detoxification (detox for short) is the physiological or medicinal removal of toxic substances from a living organism, including, but not limited to, the human body, which is mainly carried out by the liver. There are many types of detoxifications are there like alcohol detoxification, Drug detoxification, metabolic detoxification and many more. Pharmaceutical Toxicology explains the methodology and requirements of pre-clinical safety assessments of new medicines. With the focus on medicinal drugs, the most important safety issues of drugs are covered. This includes registration requirements of new drugs and Pharmacovigilance…to read more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

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Hypothalamic Pathophysiology in the Neuroimmune,Dysmetabolic and Longevity Complications of Chronic Opiate Dependency

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New conceptual and therapeutic advances in our understanding of various important pathophysiological states have remarkable relevance to current practices in the area of the treatment of opiate dependence. Major breakthroughs have recently occurred in our understanding of: The central mediation of the hypertensive-obesity-metabolic syndrome and particularly its association with the hypothalamic regulation of longevity; The ability of addictive chemical species to induce local inflammation of many parts of the CNS including the hypothalamus.

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