Legionnaires Disease

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Legionnaires disease, also called legionellosis, is caused by the bacteria Legionella pneumophila and related species. These organisms have been found in water delivery systems. The infection can be caught by inhaling mists from water contaminated with the germs. Outbreaks have been traced to contaminated whirlpool spas, humidifiers, and air conditioning cooling towers and have occurred in hospitals, hotels, and cruise ships. The incubation period for legionnaires disease is 2 to 10 days.

The disease and the organism that causes legionnaires disease were identified and got their names from the first known outbreak, at an American Legion convention held at a Philadelphia, PA, hotel in 1976.

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Late afternoon, early evening caffeine can disrupt sleep at night

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A new study shows that caffeine consumption even six hours before bedtime can have significant, disruptive effects on sleep.

Source: American Academy of Sleep Medicine

Heat in chili peppers can ease sinus problems, research shows

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Hot chili peppers are known to make people “tear up,” but a new study found that a nasal spray containing an ingredient derived from hot chili peppers may help people “clear up” certain types of sinus inflammation.

Source: University of Cincinnati Academic Health Center

No Need For Needles: Botox Sponge Treats Intrinsic Rhinitis

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Injecting botulinum toxin (botox) to treat intrinsic or allergic rhinitis may be a thing of the past as researchers have now shown that sponges soaked in botox are equally effective in treating the condition. The research offers a potential needle-free treatment to the millions of people who suffer from rhinitis.

Source: BioMed Central

NGF and APP Interplay: Focus on YENPTY Motif of Amyloid Precursor Protein and Y682 Residue:

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Cholinergic deficits originated from NGF metabolism disruption, represent one of the early changes in Alzheimer’s disease, where abnormal deposition of β-amyloid peptide (Aβ) and phosphorylated Tau define the neuropathological hallmarks of the disorder. A failure in NGF maturation can promote pro-apoptotic pathway activation, through p75 receptor; while lack of NGF signalling can generate an atypical TrkA receptor phosphorylation resulting in neuronal cell death and Aβ toxicity. These evidences suggest a complex interaction between TrkA, p75, and Aβ, whose exact cellular mechanisms remain still elusive. Here, we provide a general overview on the current knowledge on NGF and APP interplay, focusing on the events that mediate NGF signalling impairment, and, mostly, on the role of APP Tyrosine 682 phosphorylation whose absence in APPY682G mice impairs APP/TrkA interaction and leads to cholinergicneurodegeneration.

More details@ https://www.scitechnol.com/ngf-and-app-interplay-focus-on-yenpty-motif-of-amyloid-precursor-protein-and-y-residue-lDFv.php?article_id=1699

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Specificity of the Cardiocerebral-Event Reductions in the Kyoto Heart and Jikei Heart Study

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The Kyoto Heart Study was a prospective randomized open blinded end-point (PROBE)-design trial, in which 3031 Japanese patients (mean, 66 years) with uncontrolled hypertension were randomized to either valsartan add-on or non-angiotensin receptor blocker (ARB) treatment.

More details@ https://www.scitechnol.com/specificity-of-the-cardiocerebralevent-reductions-in-the-kyoto-heart-and-jikei-heart-study-IopJ.php?article_id=1851

Submit your research@https://www.scitechnol.com/submitmanuscript-international-cardiovascular-research.php


Croup in Children

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Croup is a co​mmon illness in young children. Croup is a condition that causes a swelling of the voice box (larynx) and windpipe (trachea). The swelling causes the airway below the vocal cords to become narrow and makes breathing noisy and difficult. It is most commonly caused by an infection.

Children are most likely to get croup between 3 months and 5 years of age. As they get older, it is not as common because the windpipe is larger and swelling is less likely to get in the way of breathing. Croup can occur at any time of the year.
For more information about Pediatric disorders visit: https://www.scitechnol.com/research-journal-clinical-pediatrics.php
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