Radiation dermatitis

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Irritant contact dermatitis accounts for 80% of all contact dermatitis reactions. It occurs when the skin comes in contact with a substance that acts as an irritant. Even though over 2800 substances have been identified as irritants, almost any substance under the right circumstances can act as an irritant.

Skin Barrier in Irritant Contact Dermatitis
The epidermis acts as a barrier with an outer layer composed of dead cells in a water-protein-lipid matrix.

Acute Irritant Contact Dermatitis
Acute irritant contact dermatitis occurs when the skin comes in contact with a strong toxic chemical such as an acid or alkali. The rash occurs within minutes to hours after exposure and in most cases, healing occurs soon after exposure. This rash usually has sharp borders and consists of redness, vesicles, bullae, or skin sloughing.

  • Picture of irritant contact dermatitis on the foot

Chronic Cumulative Irritant Contact Dermatitis
Chronic cumulative irritant contact dermatitis is the more common of the two. This dermatitis occurs after repeated exposure to low-level irritants, such as soaps or shampoos. The rash may take weeks, months, or even years to develop.

The rash usually has poorly-defined borders, is very itchy, and consists of redness, scaling, fissuring, and lichenification.

  • Picture of irritant contact dermatitis on the hand

Treatment of Irritant Contact Dermatitis
The mainstay of treatment for irritant contact dermatitis is avoiding as many of the irritants as possible.

Other helpful measures include:

  • Reduce water exposure – because frequent water exposure actually dries out the skin and disrupts the barrier function of the epidermis, keep water contact to a minimum.
  • Moisturize – Frequent moisturization improves the barrier function of the skin. Avoid the use of moisturizers with perfumes since these may also act as an irritant.
  • Protection – Because the hands are often affected by irritant contact dermatitis, the use of gloves may help reduce exposure to the irritant.
  • Topical steroids – Medium- to high-strength topical steroids may be needed to reduce inflammation and itching.

To Know more: https://www.scitechnol.com/clinical-dermatology-research-journal.php

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Role of Nanoparticles in Targeted Drug Delivery

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The use of nanotechnology in medicine and more specifically drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more specifically for cancer therapy.

For more related information on the article, visit us on at http://www.scitechnol.com/pharmaceutics-drug-delivery-research.php

The Significance of Beards

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Facial hair is in right now, whether it’s a subtle five o’clock shadow, a goatee, a full Duck Dynasty beard or some other variation. But beards haven’t always been this popular, and they’ve represented more than just fashion trends and primitive ways to protect your skin.

Going back to the Dynastic period in Egypt, facial hair was seen as a low class sign of animal tendencies. Men even went as far as removing their eyelashes!

As time went on, beards grew in favor. In ancient Greece, for example, beards were seen as signs of virility, manhood and wisdom. They were cut only during a time of mourning or as a form of punishment to Spartans.

The ancient Romans decided to distinguish themselves from the Greeks by being clean-shaven. It was so important to Roman culture that religious ceremonies were held when boys shaved for the first time.

By the years 330 – 1750 in Europe, facial hair had mixed support. While knights maintained beards as a sign of masculinity and honor, King Henry VIII and Queen Elizabeth weren’t fans, at least on those they ruled. King Henry kept his beard while everyone else had to pay a tax for growing one.

Forward ahead to the early 1900s in America and facial hair was not in vogue. Soldiers in WWI couldn’t have beards because they could interfere with gas masks. This led to a no-beard trend that continued until after WWII. Beards eventually made a comeback years later when they were sported by hippies and the Beatles.

Religions have different views on the topic. Christians didn’t depict Jesus with a beard until 500 CE, and early popes and bishops opposed beards. In Islam, beards are seen as an indicator of religious devotion to the Qur’an. Meanwhile, most Jewish men learn that Leviticus 19:27 maintains they can only trim and remove facial hair with scissors or, in modern times, an electric razor.

Politicians typically avoid beards because historically it was a sign of protest and later it suggested opposition to women’s issues. While many sports clubs used to have a less-than-favorable view of beards, that has changed in recent years. In 2015, more professional baseball players had beards than not.

Today, facial hair is popular enough that there is a World Beard and Mustache Championship and hipster men in New York have been known to pay more than $8,000 for facial hair transplants to fix less-than-perfect beards.

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Men With Hair Loss

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It’s a significant riddle technology has yet to completely solve, but there’s definite progress. Male pattern baldness is that mysterious condition that has enormous social significance but almost no medical significance and it’s been a great boon to the baseball cap industry, of course.

In this survey, we take the pulse of American men who have experienced hair loss, to understand three primary things: how men respond to that hair loss (with treatments or lack thereof), what motivates their responses, and how they feel about the subject overall.

The first order of business for us was to establish how much hair men are losing. Between thinning hair and more significant hair loss that results in bald spots, widow’s peaks and full baldness, it’s a fifty-fifty split. Among the half of men experiencing more severe hair loss, 43 percent report having a bald spot or widow’s peak and seven percent report they are fully bald. Naturally, the response to hair loss is informed by the amount of hair that’s been lost, so it’s important to keep these baselines in mind.

Surprising or not, a majority of men do very little to address their hair loss (particularly in the Northeast)—50 percent have responded by cutting their hair short or shaving it all off, while an additional one in four men don’t do anything different as their hair begins to disappear.

The least likely response is to go under the knife—just one percent of men undergo hair transplant surgery. Much more popular are shampoo treatments and medications like Rogaine and Propecia, the former being a spray, the latter being oral medication.
Guys on the West Coast are by far the most likely to explore over-the-counter treatments—nearly twice as many men experiencing hair loss on the West Coast have tried shampoos, than men in the Northeast. West Coast men are also most likely to have used sprays or medications: 34 percent on the West Coast have tried, versus an average of 18 percent throughout the rest of the country.

What motivates a particular guy’s response to his hair loss? Well, it’s not all about sex appeal. The most common answer was that doing something about it makes men feel more confident (sex appeal aside). That said, one in four men copped to wanting to enhance his sex appeal. Just behind that, statistically, was a desire to “fit in.” And the reasons men were least likely to cite as motivators to do something about their hair loss? It’s important to their work… or their significant other.

To know more: http://bit.ly/1QM6nmv
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Hydrogels Incorporated with Cancer Medicines

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Electric-field sensitive hydrogels are of great interest for many researchers from the aspects of their usage in several biomaterials applications. Controllable drug release under various voltages offers huge benefits for the controlled drug delivery systems. Electrically sensitive polyvinyl alcohol (PVA) hydrogels loaded with methotrexate (MTX) and other compounds were prepared via a solution casting process, and characterized through various techniques.

To view the full information on the article, visit us on at http://www.scitechnol.com/pharmaceutics-drug-delivery-research.php

Homology Modeling of Versatile Peroxidases from Pleurotus sapidus Reveals Residues for Site Directed Mutagenesis to Enhance the Bioremediation Ability

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Ligninolytic enzymes have potential applications in many fields and they are involved in the degradation of various xenobiotic compounds and dyes. Versatile peroxidases, a fungal enzyme, are industrially attractive and their applications have expanded to the field of bioremediation. Designing an enzyme that have higher catalytic activity, stability and fitting well with the required conditions are one of the challenges of today’s biotechnology. Versatile peroxidases are known to efficiently oxidize non-natural substrates like polycyclic aromatic hydrocarbons (PAHs). The accessibility of the PAHs to microbial cells is less. Hence by increasing the hydrophobicity of versatile peroxidases, the chance of the enzyme to meet the hydrophobic substrates such as PAHs in a contamination site can be increased. We have used an insilico approaches for optimal designing of versatile peroxidase to enhance its bioremediation ability.


A Unified Bug Testing Software for Biological and Other Systems

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Automatic bug testing is very crucial for software systems that are widely used. This is especially true when the system is very complex. Unexpected and undesired events could happen due to the presence of bugs. For instance, a web system might take a very long time on a specific query because of the presence of a bug. We cannot expect the creators of the web system to be continually monitoring the system looking for such events. It will greatly benefit the creators of the web system if such events can be automatically detected and if they are notified in a timely fashion. In this paper we report one such bug testing software that we have created for the MnM web system for motif search. MnM is widely used by biologists all over the globe. We feel that the architecture we have employed for our bug testing software is generic and can be applied to other software systems as well. There exist numerous conventional bug testing software tools which are designed to perform only functional or graphical user interface testing.


A Rarely Seen Entity: Morbus Morbihan Disease

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Morbus Morbihan disease is granulomatous complication characterized with facial edema occuring due to acne or rosacea. It is resistant to treatment; diagnosis could be difficult. 48 years old male patient applied to our polyclinic with complaint of swelling on left side of his face, around his eye and cheeks, persistent for 6 months. He previously applied to dermatology, dental and Otorhinolaryngology departments in various hospitals but no diagnosis could be made. There was no trauma, exposure to sun, drug use history or symptoms like pain and itch. He was complaining about visual swelling. He had edema stretching from left side of his face to orbital area and mild erythema in his dermatological examination. Our pathology department reevaluated biopsy preparations taken by the center he previously went. Rosacea lymphedema was reported. Doxycycline, ornidazole, ketotifen and flutamide were administered by assuming that patient has Morbus Morbihan disease. In the next examination after one month, it has been observed that edema was diminished. In fourth month, edema decreased a lot. Thus treatment was stopped. The patient was applied again in the following 2 months due to increase at edema on his face. That time 0.5 mg/day isotretinoin treatment started and at third month edema regressed. We found this case appropriate to present to emphasize that it is rare and that it should be considered.

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Healthcare Demographics and Specialty Variation in Atopic Dermatitis

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Importance: Atopic dermatitis (AD) is a common chronic skin disease with significant comorbidities and a dramatic impact on quality of life. Despite this, there is little-published information about healthcare utilization patterns for adults and children with AD.
Objective: To examine healthcare utilization for patients with AD who are cared for in a regional academic medical center.
Design: Retrospective cohort analysis. Setting: A mixed urban, suburban and rural catchment in the Western NY region.
Participants: All patients seeking medical care for their AD from March of 2011 to September 2015.
Main Measure(s): Age, sex, race, ethnicity, (demographics) and medical specialty (healthcare utilization). Patients were stratified and analyzed by age group.
Results: Adult AD patients (n=767) accounted for 38.2% of the AD population seeking healthcare in our system with a mean age of 42.7 ± 18.7 years. Among adults, females were seen more commonly than males (65.3% vs. 34.7%). In contrast, both genders were equally represented in the pediatric population (18 years; 35.2%). Dermatologists cared for the majority of patients (35.2%), followed by pediatricians (25.7%) and family medicine physicians (10.1%). African-Americans were nearly 3 times more likely than Caucasians to visit primary care physicians for their initial AD management (p<0001).
Conclusions and relevance: This study demonstrates that adult AD patients account for over a third of all AD visits in a regional academic medical center. Dermatologists managed the greatest number of AD patients, and the pediatric population was notable for a greater proportion of African American patients relative to the adults. This disparity between the proportions of African Americans in pediatric vs adult patients may reflect reduced access to care for adults. Alternatively, African-Americans may simply have a greater prevalence of pediatric onset AD coupled with greater disease resolution prior to adulthood. African-Americans also appear to seek

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Ways to Treat Damaged Hair in Winter

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It’s been a rough winter for most of the country. When you’ve got arctic temperatures and gusting winds you’ve also got low humidity in the air. And low humidity not only dries out your skin but also dries out your #hair. If your hair is feeling dry and brittle and is seeking the summer warmth, then read on.

Here are four tips to help you repair your damaged winter hair:

1. Reduce shampooing. Shampooing every second or third day will allow natural oils to remain on your hair and scalp and prevent further drying.

2. Go deep. Once to twice a week, massage a deep conditioner into your hair and scalp and let it rest as you shower. Then rinse with warm water. For extremely dry hair, try using a leave-in deep conditioner or conditioning hair mask that you apply before bedtime and rinse the following morning. Be sure to wear a hair net and to place a towel on your pillow so you don’t stain your bed sheets.

3. Go natural. Using hair dyers and other heating devices take a toll on your hair. When possible, allow your hair to air-dry, but aim for at least once to twice a week.

4. Cool off. Some women who chemically treat their hair (think highlights) and use heating devices regularly (think flatirons), develop trichorrhexis nodosa, or hair breakage. Once hair is broken, you can’t fix it. You can minimize additional damage by reducing usage of heating devices. Try every second or third day instead of every day.

To know more: http://bit.ly/1QM6nmv
Submit your manuscript: dermatology@scitechnol.com (or) dermatology@scitechnol.org

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Research examining the prevalence of Intimate Partner Violence (IPV) is limited by a lack of comprehensive measurement tools. While the Composite Abuse Scale (CAS) was designed to assess multiple forms of partner abuse, to date it has been primarily used in clinical samples and has not been applied to the broader community. Read more at […]

via The Community Composite Abuse Scale: Reliability and Validity of a Measure of Intimate Partner Violence in a Community Survey from the ALSWH — SciTechnol Blog

The Community Composite Abuse Scale: Reliability and Validity of a Measure of Intimate Partner Violence in a Community Survey from the ALSWH

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Research examining the prevalence of Intimate Partner Violence (IPV) is limited by a lack of comprehensive measurement tools. While the Composite Abuse Scale (CAS) was designed to assess multiple forms of partner abuse, to date it has been primarily used in clinical samples and has not been applied to the broader community.

Read more at https://www.scitechnol.com/womens-health-issues-care.phpObscene-a

Post-Date Extrauterine Abdominal Pregnancy in a Rhesus Negative Nullipara with Successful Outcome

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Abdominal pregnancy is becoming a nightmare to many obstetricians and it represents just about 1% of ectopic pregnancies. Since its first report in 1708, copious cases have been published subsequently. The diagnosis is usually intricate except if there are complications such as abdominal pain and haemorrhage. Maternal mortality and morbidity are also very high principally if the condition is not diagnosed and managed appropriately. By and large, abdominal pregnancies do not attain to or go beyond 37 weeks of gestation.

Read more at https://www.scitechnol.com/womens-health-issues-care.phpectopic-pre

Emerging Drugs

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Emerging Drugs are newly formed drugs use for the disease treatment having psychological effect after introducing in the body. Drug therapy also referred to as pharmacotherapy, is a common terminology often used in the field of biomedical science as well as epidemiology. It is a well acknowledged fact that the efficacy of the prescribed drug relies on the specific receptors and the interaction between the drug and its specific receptor encourages the healthy functioning of the cells. Drug therapy is the treatment of disease through the administration of drugs. As such, it is considered part of the larger category of therapy. Pharmacists are experts in pharmacotherapy and are responsible for ensuring the safe, appropriate, and economical use of medicines. The mode of drug intake varies from one person to the other and also depends on the condition of the patient undergoing the therapy. Although, the employed therapies free the patient from the ailment, occurrence of side effects cannot be ruled out. But these side effects are transitory and will last for a short period of time. Hence in most cases, the side effects will not last beyond the course of treatment…to read more:  https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

Submit Manuscript: editor.jpsed@scitechnol.com or editor.jpsed@scitechnol.org

Medicinal Chemistry

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Medicinal chemistry is the chemistry discipline concerned with the design, development and synthesis of pharmaceutical drugs. It combines expertise from chemistry and pharmacology to identify, develop and synthesize chemical agents that have a therapeutic use and to evaluate the properties of existing drugs. Medicinal Organic chemistry deals with the structure, properties, and reactions of Pharmacoanalysis, the chemical analysis and organic compounds. Medicinal Organic Chemistry Letters will be merged with Chemistry section. Medicinal chemical research is disclosure of novel experimental achievements. Medicinal chemical research feats in many facets of drug design, drug discovery and the elucidation of mechanisms of action of biologically active compounds. Applied Medicinal Chemistry in its most common practice focusing on small organic molecules. Applied Medicinal Chemistry encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Medical biochemistry is a field that studies different types of molecules in hopes of bettering technology and medicine….to read more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

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Feasibility of Single Tumorspot Treatment in Peritoneal Carcinomatosis via Close Range Doxorubicin Impaction in Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC)

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Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a well-established, yet not fully evaluated new treatment approach for peritoneal carcinomatosis with the aim at enabling localized application of chemo aerosol within the abdominal cavity. Distribution inhomogeneity in PIPAC has been previously indicated in prior experiments. This study was conducted to investigate whether this finding can be used to achieve localized high drug concentrations into micro metastasis. PIPAC construct was built using a hermetic container system which mimics the abdominal cavity. Fresh parietal peritoneum portions from post-mortem swine were cut into samples and placed vertically in the center of a box. The Micropump© (MIP) was introduced via trocar at the side of the box and located at 1cm from the samples to enable close range impaction of the aerosolized doxorubicin with the samples. Doxorubicin penetration depth was radially measured by fluorescence microscopy from the center of targets to the outer rim. Tissue doxorubicin penetration in the tissue was lower towards the outer rim and further away from the center of the sprayjet. Maximal penetration of drug was achieved in the midpoint of the sprayjet with 417± 87(SD) µm and a minimal penetration was reached at 3 cm from center with 45 ± 20 (SD) µm….to read more: https://www.scitechnol.com/peer-review/feasibility-of-single-tumorspot-treatment-in-peritoneal-carcinomatosis-via-close-range-doxorubicin-impaction-in-pressurized-intrap-sG1B.php?article_id=6082

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Tetraspnin CD151 is involved in proliferation, motility, and invasion. Yet, the role of CD151 in estrogen receptor positive breast cancer is not reported. In the present study, the role of CD151 in survival of ER positive cell line and the underlying molecular partners was reported. CD151 shRNA expression vector was transfected into MCF-7 cells and its efficacy was evaluated by RT-PCR. The capacity of proliferation, migration, and invasion, cell adhesion, angiogenesis of MCF-7 cells was diminished by the knockdown of CD151 via CD151 specific shRNA. It arrested the cell cycle at G2/M phase and induced the apoptosis. The expressions of c-myc, α3β1 integrin, IL-8, Ras, FAK and VEGF were reduced by knockdown of CD151. The results conclude that CD151 gene silencing affects the expression of its network partner’s associate with survival of MCF-7 cells. Therefore, CD151 may be a potential target of luminal and basal subtypes…..to read more: https://www.scitechnol.com/peer-review/knockdown-of-cd151-gene-expression-reduces-survival-of-estrogen-receptor-positive-breast-cancer-cells-mC1L.php?article_id=6081

To know more: https://www.scitechnol.com/clinical-experimental-oncology.php

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