Toxic
Release Kinetics of Cellulosic Nano particulate Formulation for Oral Administration of an Antiviral Drug: Effect of Process and Formulation variables
Recently, researchers have increasing interest in cellulosic polymers for optimizing the efficiency of existing drugs utilizing better-designed drug delivery systems. In the present research nanoparticles were prepared using cellulose esters to obtain a drug product with a good oral bioavailability and biological half-life. Acyclovir (ACY) was formulated by combining the modified solvent evaporation/extraction technique, sonicator and high pressure homogenization approaches. Various formulation parameters such as sonication-time, concentration of cellulose esters and surfactants were studied. Nanoparticles were obtained with enhanced encapsulation efficiency, negatively charged, defined shape, size and with homogeneous size distribution.
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Necrotic Arachnidism by Zorocrates guerrerensis
The spiders (filo Arthropoda) occupy seventh place in global species richness. The genus Zorocrates Simon, consists of endemic species in Mexico. This arthropod used for feeding or defense, glandular secretions to manipulate their prey (including human), affecting their state of health or causing the death, by what are considered species of medical importance.
We present the case clinical female 19 years old, resident of the Mexico City, who came to the Parasitology Laboratory, National Autonomous University of Mexico (UNAM), commenting that three days before, sitting on his bed, felt pain in the left external tibial region at the level of the third half, discovering a large insect, repelling it immediately; minutes later, there are burning, and erythema in the area of reference, which evolves with formation of vials, which spontaneously bursts. Then presented erythematous, itchy, painful plaques, reason for the requested medical attention. The ulcerative lesion studied with slow progress until the cicatricial process.
Responsible arachnid is presented to the laboratory until the end of the treatment, which is identified as Zorocrates guerrerensis, species located in areas of the Mexico City (bedrooms, bathrooms, patios, zotehuelas, cisterns and gardens). There are no cases reported in Mexico and the world, about accidents caused by this species. It is suggested that the injury is due to the mechanics of the bite and not by the toxic effects of its secretion, which has not yet been characterized and that cannot be ruled out, along with other components, as head of the pathophysiological manifestations.
Read more: http://bit.ly/2lCw3qi
Submit your manuscript: dermatology@scitechnol.com (or) dermatology@scitechnol.org
https://scitechnolblog.wordpress.com/2017/02/25/necrotic-arachnidism-by-zorocrates-guerrerensis/
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