skin

Toxin-Producing Bacteria

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Our skin is covered with bacteria as part of our normal skin microbiome and typically serves as a barrier that protects us from infection and inflammation. However, when that barrier is broken, the increased exposure to certain bacteria really causes problems,” says Lloyd Miller, M.D., Ph.D., associate professor of dermatology at the Johns Hopkins University School of Medicine.

The bacteria Staphylococcus aureus, or S. aureus, is an important human pathogen and the most common cause of skin infections in people. Miller says, “20 to 30 percent of the U.S. population have S. aureus living on their skin or in their nose, and over time, up to 85 percent of people come into contact with it. Eczema is an inflammatory skin disease that affects 20 percent of children and about 5 percent of adults. Ninety percent of patients with eczema have exceedingly high numbers of S. aureus bacteria on their inflamed skin.”

It was previously shown by others that a rare disease called generalized pustular psoriasis (in which the skin erupts into pustules) was caused by a genetic mutation that resulted in the unrestrained activity of a protein normally produced in our skin, called IL-36. This, says Miller, was a clue that IL-36 might have something to do with how bacteria on the skin surface induce inflammation. So they set out to test this idea in mice. They soaked a small gauze pad with S. aureus and applied it to the back skin of normal mice and those that had been genetically engineered to lack the receptor for IL-36 that triggers inflammatory responses. Miller’s team found the normal mice developed scaly and inflamed skin, and the genetically engineered mice lacking IL-36 activity had almost no skin inflammation.

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Artificial Intelligence helps Early Diagnosis of skin cancer

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The technology employs machine-learning software to analyze images of skin lesions and provide doctors with objective data on telltale biomarkers of melanoma, which is deadly if detected too late, but highly treatable if caught early.

The AI system — trained using tens of thousands of skin images and their corresponding eumelanin and hemoglobin levels — could initially reduce the number of unnecessary biopsies, a significant health-care cost. It gives doctors objective information on lesion characteristics to help them rule out melanoma before taking more invasive action.

The technology could be available to doctors as early as next year.

E-mail us: dermatology@scitechnol.com

https://www.scitechnol.com/clinical-dermatology-research-journal.php

Efficacy of a Topical Lotion Containing Lactoferricin, Glycerophosphoinositol Lysine and Verbascoside for External Otitis Due to Atopic Dermatitis

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The prevalence of atopic dermatitis (AD) in the general dog population is 3-15% it represents the diagnosis for up to 58% of dogs affected with skin disease. Canine AD has been defined by Halliwell in 2006, as a “genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features, associated with IgE antibodies most commonly directed against environmental allergens”. Indeed, genetic factors and familiar predisposition to the disease have been found to play a major role in its pathogenesis, although the full pathogenesis is still unknown. It is certain that the immunological aberration is usually associated with skin barrier dysfunctions; pro-inflammatory cytokines, neuronal itch stimuli and the animal’s pruritic behaviours establish a vicious cycle of itch that perpetuates and potentially exacerbates the skin lesions and defects in the skin barrier function. The initial clinical feature of canine AD is pruritus, which at the beginning may be associated with no lesion or with primary skin lesions such as erythema and occasionally papules. The mediators that elicit the sensation of pruritus have not been elucidated, but histamine does not appear to be a mediator in dogs in contrast to humans and mice. It is usually a life-long pathology which can be controlled, but it can be seldom cured. The diagnosis of canine AD does not require any analytical test, such as IgE determination and/or intradermal skin test, and it can be done on the basis of pruritus associated with skin lesions. The skin lesions are usually associated with the detachment of corneocytes from live skin. Furthermore, the skin lesions are usually associated with the cytological presence and overgrowth of bacteria (mainly Staphylococcus) and fungal or yeast (mainly Malassezia Pachydermatis) in the damaged region, and it has been purpose that this overgrowth could be also responsible for most of the symptoms. Due to the skin infection, canine AD often develops otitis externa and usually, the signs of atopic otitis were noticed by the owners before the other signs of AD.

E-mail us: dermatology@scitechnol.com

 

2-Octyl Cyanoacrylate Skin Adhesive

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Surgical adhesives have become more prevalent in the Emergency Department (ED) to close #skin lacerations due to their ease of use, more complete surface contact and microbial barrier properties. They also have unique advantages over traditional suturing in the ED. This includes the ease of closure, the speed of closure, decreased or elimination of the need for topical or injectable anaesthetics, and reducing the need for specific aftercare including suture removal. Prior research has found that liquid skin adhesives for laceration closure are less painful and produce similar cosmetic effects when compared to sutures. While skin adhesives offer advantages opportunities for improvement exist. Ease of application is an important characteristic. The viscosity of the adhesive may cause problems if too low, flowing into sensitive areas including eyes and mucous membranes. If too high it may not adequately cover the wound or create a raised area that patients may find irritating, particularly children who may scratch at these raised areas which can increase the risk of infection.

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Full Article: http://bit.ly/2hnIl3W

L 17 Cytokine in Psoriasis

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Psoriasis which was considered a disease of abnormal epidermal keratinocyte proliferation later was identified as T helper-1 (Th1) disease because an increase in Th1 pathway cytokines was observed in the lesions and in serum. Currently, a new paradigm has emerged where Th17 cells which produce IL-17 and IL-22, play a central role in the pathogenesis of psoriasis. The differentiation factors (TGF-beta, IL-6, IL-21), the growth and stabilization factor (IL-23), and the intracellular transcription factors (STAT3, RORγt, and RORalpha) are involved in the development of Th17 cells. IL-17A, part of a group of cytokines, called the IL-17 family plays a critical role in the pathogenesis of psoriasis. IL-17A enhances the expression of S100 proteins, chemokines CCL20, CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8, and VEGF in keratinocytes leading to aberrant cell differentiation, proliferation, and immune activation. IL-17A has pleiotropic effects, but its main effect is recruitment and activation of neutrophils, angiogenesis and tissue remodelling by stimulating the production of angiogenic factors and matrix metalloproteases.

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Full article: http://bit.ly/2s0aKDF

Get the Best Results From Beauty Products

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It is certainly not from exotic ingredients or brand-name only products. Obtaining great results depend on having a complete skin care routine. This routine should consist of skin-compatible products, targeted for your desired results. For example, if acne is your main focus, purchase products that combat acne. If lines and wrinkles are bothering you, don’t overload and complicate your product usage. Choose items that target your issues.

It’s actually that simple. Complete skin care means you ‘dot the essential I’s and cross the essential T’s’. And here’s where you start.

  • Cleanse skin to prepare it to absorb corrective actives.
  • Correct skin problems by choosing specific products designed to achieve your results.
  • Hydrate to maintain skin health.
  • Protect from damaging UV rays that lead to wrinkles and uneven skin pigment.

Ensure each step includes quality products. This is the secret to skin care that is repeatedly missed. Don’t be deceived by advertising claims enticing you to the latest and greatest! Learn why complete skin care is important.

While you’re at it, see my advice pages below. They will guide you to creating an effective routine for the results you want!

Read More: https://www.scitechnol.com/clinical-dermatology-research-journal.php

E-mail us: dermatology@scitechnol.com

Necrotic Arachnidism by Zorocrates guerrerensis

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The spiders (filo Arthropoda) occupy seventh place in global species richness. The genus Zorocrates Simon, consists of endemic species in Mexico. This arthropod used for feeding or defense, glandular secretions to manipulate their prey (including human), affecting their state of health or causing the death, by what are considered species of medical importance.

We present the case clinical female 19 years old, resident of the Mexico City, who came to the Parasitology Laboratory, National Autonomous University of Mexico (UNAM), commenting that three days before, sitting on his bed, felt pain in the left external tibial region at the level of the third half, discovering a large insect, repelling it immediately; minutes later, there are burning, and erythema in the area of reference, which evolves with formation of vials, which spontaneously bursts. Then presented erythematous, itchy, painful plaques, reason for the requested medical attention. The ulcerative lesion studied with slow progress until the cicatricial process.

Responsible arachnid is presented to the laboratory until the end of the treatment, which is identified as Zorocrates guerrerensis, species located in areas of the Mexico City (bedrooms, bathrooms, patios, zotehuelas, cisterns and gardens). There are no cases reported in Mexico and the world, about accidents caused by this species. It is suggested that the injury is due to the mechanics of the bite and not by the toxic effects of its secretion, which has not yet been characterized and that cannot be ruled out, along with other components, as head of the pathophysiological manifestations.

Read more: http://bit.ly/2lCw3qi

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https://scitechnolblog.wordpress.com/2017/02/25/necrotic-arachnidism-by-zorocrates-guerrerensis/