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Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats

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GSPE or gallic acid supplementation did not reduce weight gain or reverse and adiposity. However, GSPE reduced adipocyte size significantly in rWAT and moderately in iWAT and tripled the adipocyte number in rWAT. Gallic acid slightly reduced adipocyte size in rWAT and iWAT and doubled the adipocyte number in both WATs. In accordance with this adipogenic activity, Pref-1 and PPARγ tended to be overexpressed in rWAT of rats supplemented with GSPE. Moreover, GSPE supplementation increased Plin1 and Fabp4 expression and restored adiponectin expression completely, indicating a better functionality of visceral WAT.

GSPE supplementation has anti-hypertrophic and hyperplasic activities in rats with established obesity, mainly in visceral WAT inducing a healthier expansion of WAT to match the surplus energy provided by the cafeteria diet.

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Newborn insula gray matter volume is prospectively associated with early life adiposity gain

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Insula GM volume was inversely associated with change in percent body fat from birth to six-months postnatal age and accounted for 19% of its variance (β=−3.6%/S.D., P=0.001). This association was driven by the central-posterior portion of the insula, a region of particular importance for gustation and interoception. The direction of this effect is in concordance with observations in adults, and the results remained statistically significant after adjusting for relevant covariates and potential confounding variables. Altogether, these findings suggest an underlying neural basis of childhood obesity that precedes the influence of the postnatal environment. The identification of plausible brain-related biomarkers of childhood obesity risk that predate the influence of the postnatal obesogenic environment may contribute to an improved understanding of propensity for obesity, early identification of at-risk individuals, and intervention targets for primary prevention.

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Childhood obesity a ‘time-bomb’

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The study found that being obese or overweight from as early as three years of age increased the chances participants would have a high cardiovascular risk later in life. According to a recent New Zealand health survey, 11% of children were obese and a further 21% overweight. ‘This means we are facing a real time-bomb in terms of the potentially enormous burden of ill-health in a substantial proportion of our population,”These findings are important because determining an association early on may help provide further impetus for interventions to prevent overweight and obesity beginning in early childhood with the goal of improving long-term cardiovascular health.

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Drinking diet beverages during pregnancy linked to child obesity

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Children born to women who had gestational diabetes and drank at least one artificially sweetened beverage per day during pregnancy were more likely to be overweight or obese at age 7, compared to children born to women who had gestational diabetes and drank water instead of artificially sweetened beverages, according to a study led by researchers at the National Institutes of Health. Childhood obesity is known to increase the risk for certain health problems later in life, such as diabetes, heart disease, stroke and some cancers.

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Your brain, not your stomach, tells you when to stop eating

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Cholecystokinin:

A hormone produced by your digestive system, called cholecystokinin, signals your brain when you’ve eaten. More is released in a large meal and less from a small snack. When you are dieting to lose weight, your stomach counterbalances the reduced food intake by cutting back on the amount of this hormone it will release, encouraging you to eat more and go off your diet. Loading up on fiber will help you circumvent this built-in survival tool.

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The food industry is behaving as the tobacco industry

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Increasingly, the question of what we eat and how it affects our health is a subject that is important not just to those concerned about nutrition but to environmentalists. Food Fight, Brownell has recently become interested in the connections between obesity, the environment, and hunger, believing that sustainably growing and producing more nutritious foods can help solve each of these challenges. this is a perfect repeat of what tobacco did for many years. They said smoking doesn’t cause lung cancer. There is not definitive evidence. There aren’t good-enough studies. It’s junk science. It’s just the advocates out to get us. And then they denied that second-hand smoke was killing people. They denied that nicotine was addictive. You can go on and on and on. Well, so here comes a (food) study that’s pretty persuasive. It certainly supports other studies showing a link between fast food consumption and obesity, and what did they do? They trashed the science. They deny it’s the case. In all likelihood, they will pay scientists who they know to produce results favourable to them to disprove this finding.

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Obesity in adolescence may cause permanent bone loss

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Obesity in childhood and adolescence is associated with a number of health risks, including cardiovascular disease and diabetes. For the new study, researchers are looking at how excess weight may affect bone structure.

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