Dermatology

Efficacy of a Topical Lotion Containing Lactoferricin, Glycerophosphoinositol Lysine and Verbascoside for External Otitis Due to Atopic Dermatitis

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The prevalence of atopic dermatitis (AD) in the general dog population is 3-15% it represents the diagnosis for up to 58% of dogs affected with skin disease. Canine AD has been defined by Halliwell in 2006, as a “genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features, associated with IgE antibodies most commonly directed against environmental allergens”. Indeed, genetic factors and familiar predisposition to the disease have been found to play a major role in its pathogenesis, although the full pathogenesis is still unknown. It is certain that the immunological aberration is usually associated with skin barrier dysfunctions; pro-inflammatory cytokines, neuronal itch stimuli and the animal’s pruritic behaviours establish a vicious cycle of itch that perpetuates and potentially exacerbates the skin lesions and defects in the skin barrier function. The initial clinical feature of canine AD is pruritus, which at the beginning may be associated with no lesion or with primary skin lesions such as erythema and occasionally papules. The mediators that elicit the sensation of pruritus have not been elucidated, but histamine does not appear to be a mediator in dogs in contrast to humans and mice. It is usually a life-long pathology which can be controlled, but it can be seldom cured. The diagnosis of canine AD does not require any analytical test, such as IgE determination and/or intradermal skin test, and it can be done on the basis of pruritus associated with skin lesions. The skin lesions are usually associated with the detachment of corneocytes from live skin. Furthermore, the skin lesions are usually associated with the cytological presence and overgrowth of bacteria (mainly Staphylococcus) and fungal or yeast (mainly Malassezia Pachydermatis) in the damaged region, and it has been purpose that this overgrowth could be also responsible for most of the symptoms. Due to the skin infection, canine AD often develops otitis externa and usually, the signs of atopic otitis were noticed by the owners before the other signs of AD.

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2-Octyl Cyanoacrylate Skin Adhesive

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Surgical adhesives have become more prevalent in the Emergency Department (ED) to close #skin lacerations due to their ease of use, more complete surface contact and microbial barrier properties. They also have unique advantages over traditional suturing in the ED. This includes the ease of closure, the speed of closure, decreased or elimination of the need for topical or injectable anaesthetics, and reducing the need for specific aftercare including suture removal. Prior research has found that liquid skin adhesives for laceration closure are less painful and produce similar cosmetic effects when compared to sutures. While skin adhesives offer advantages opportunities for improvement exist. Ease of application is an important characteristic. The viscosity of the adhesive may cause problems if too low, flowing into sensitive areas including eyes and mucous membranes. If too high it may not adequately cover the wound or create a raised area that patients may find irritating, particularly children who may scratch at these raised areas which can increase the risk of infection.

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Full Article: http://bit.ly/2hnIl3W

L 17 Cytokine in Psoriasis

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Psoriasis which was considered a disease of abnormal epidermal keratinocyte proliferation later was identified as T helper-1 (Th1) disease because an increase in Th1 pathway cytokines was observed in the lesions and in serum. Currently, a new paradigm has emerged where Th17 cells which produce IL-17 and IL-22, play a central role in the pathogenesis of psoriasis. The differentiation factors (TGF-beta, IL-6, IL-21), the growth and stabilization factor (IL-23), and the intracellular transcription factors (STAT3, RORγt, and RORalpha) are involved in the development of Th17 cells. IL-17A, part of a group of cytokines, called the IL-17 family plays a critical role in the pathogenesis of psoriasis. IL-17A enhances the expression of S100 proteins, chemokines CCL20, CXCL1, CXCL3, CXCL5, CXCL6, and CXCL8, and VEGF in keratinocytes leading to aberrant cell differentiation, proliferation, and immune activation. IL-17A has pleiotropic effects, but its main effect is recruitment and activation of neutrophils, angiogenesis and tissue remodelling by stimulating the production of angiogenic factors and matrix metalloproteases.

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Full article: http://bit.ly/2s0aKDF

Sexually Transmitted Infections among Sex Workers

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Sexually transmitted infections (STIs) are a major public health concern in developing countries. They are increasing with the advent of human immunodeficiency virus (HIV) infection, particularly in sub-Saharan Africa. Sex workers (SWs) are the most vulnerable population.

A cross-sectional and prospective survey was conducted at the STIs clinic in Cotonou, from November 2014 to April 2015. The STI clinic is currently the reference centre for the care of SWs and their clients in Cotonou. The SWs and their clients who consulted in the STI clinic for any reason were included with their informed consent. The diagnosis of STI was essentially based on the syndromic approach. Further medical tests were requested when necessary. Retroviral serology was performed free of charge for all included patients. Recruitment was based on a thorough sampling. The data collected with a survey form were analyzed with the Epi Info 7 software, which received the approval of the local ethics committee. Anonymity and confidentiality were respected in the processing of files.

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Get Article: http://bit.ly/2vSjxeC

Get the Best Results From Beauty Products

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It is certainly not from exotic ingredients or brand-name only products. Obtaining great results depend on having a complete skin care routine. This routine should consist of skin-compatible products, targeted for your desired results. For example, if acne is your main focus, purchase products that combat acne. If lines and wrinkles are bothering you, don’t overload and complicate your product usage. Choose items that target your issues.

It’s actually that simple. Complete skin care means you ‘dot the essential I’s and cross the essential T’s’. And here’s where you start.

  • Cleanse skin to prepare it to absorb corrective actives.
  • Correct skin problems by choosing specific products designed to achieve your results.
  • Hydrate to maintain skin health.
  • Protect from damaging UV rays that lead to wrinkles and uneven skin pigment.

Ensure each step includes quality products. This is the secret to skin care that is repeatedly missed. Don’t be deceived by advertising claims enticing you to the latest and greatest! Learn why complete skin care is important.

While you’re at it, see my advice pages below. They will guide you to creating an effective routine for the results you want!

Read More: https://www.scitechnol.com/clinical-dermatology-research-journal.php

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Necrotic Arachnidism by Zorocrates guerrerensis

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The spiders (filo Arthropoda) occupy seventh place in global species richness. The genus Zorocrates Simon, consists of endemic species in Mexico. This arthropod used for feeding or defense, glandular secretions to manipulate their prey (including human), affecting their state of health or causing the death, by what are considered species of medical importance.

We present the case clinical female 19 years old, resident of the Mexico City, who came to the Parasitology Laboratory, National Autonomous University of Mexico (UNAM), commenting that three days before, sitting on his bed, felt pain in the left external tibial region at the level of the third half, discovering a large insect, repelling it immediately; minutes later, there are burning, and erythema in the area of reference, which evolves with formation of vials, which spontaneously bursts. Then presented erythematous, itchy, painful plaques, reason for the requested medical attention. The ulcerative lesion studied with slow progress until the cicatricial process.

Responsible arachnid is presented to the laboratory until the end of the treatment, which is identified as Zorocrates guerrerensis, species located in areas of the Mexico City (bedrooms, bathrooms, patios, zotehuelas, cisterns and gardens). There are no cases reported in Mexico and the world, about accidents caused by this species. It is suggested that the injury is due to the mechanics of the bite and not by the toxic effects of its secretion, which has not yet been characterized and that cannot be ruled out, along with other components, as head of the pathophysiological manifestations.

Read more: http://bit.ly/2lCw3qi

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https://scitechnolblog.wordpress.com/2017/02/25/necrotic-arachnidism-by-zorocrates-guerrerensis/

Skin Cancer on the Rise

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The researchers report that, between 2000 and 2010, squamous cell carcinoma (also called cutaneous squamous cell carcinoma) diagnoses increased 263 percent, and basal cell carcinomas increased 145 percent. They compared the 2000-2010 period to two other segments of time: 1976-1984 and 1985-1992.

Women 30-49 experienced the greatest increase in basal cell carcinoma diagnoses; whereas, women 40-59 and 70-79 experienced the greatest increase in squamous cell carcinomas.

Men had an increase in squamous cell carcinomas between the first and second time period studied (1976-1984 and 1985-1992), but experienced a slight decline in the 2000-2010 period. However, for basal cell carcinomas, men over 29 showed similar increases in diagnoses in the 2000-2010 period than the two earlier periods.