Genetics & Molecular Biology

Using CRISPR and skin grafts, researchers boost insulin levels to reduce weight

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Scientist has now overcome challenges that have limited the use of gene therapy. They demonstrate how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat human diseases. The researchers provide ‘proof-of-concept,’ treating mice with two common related human ailments: type-2 diabetes and obesity.

https://www.scitechnol.com/journal-genes-and-proteins.php

 

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Unique gene therapy prevents, reverses multiple sclerosis in animal model

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Multiple sclerosis can be inhibited or reversed using a novel gene therapy technique that stops the disease’s immune response in mouse models, researchers have found. Multiple sclerosis can be inhibited or reversed in mouse models using a novel gene therapy technique to suppress the immune response that induces the disease. The researchers used a harmless virus, known as an adeno-associated virus or AAV, to deliver a gene coding one of the common immune targets, a myelin sheath protein called myelin oligodendrocyte glycoprotein or MOG, into the livers of the mouse models. The protein leads to the production of so-called regulatory T cells, which suppress the rogue immune system cells responsible for attacking the protective layer of nerve cells that defines multiple sclerosis. The effectiveness of this approach is based on targeting the gene therapy to the liver, which promotes immune tolerance.

https://www.scitechnol.com/journal-genes-and-proteins.php

Hypoxic Fetal Brain Damage Followed by Cerebral Palsy will be Prevented by Computerized Fetal Monitoring

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Diagnostic tool to detect fetal risk in the birth process, instead of listening to fetal heart sound, mother’s abdominal fetal ECG, PCG and ultrasound CW Doppler fetal heart detector, while the subjective FHR pattern diagnosis had been widely used in the world since 1968, but it was based on subjective visual pattern recognition, where the diagnosis was disturbed by vague definition and observer difference [1]. The author noticed its controversy nature based on subjective human visual FHR observation, and created objective numeric FHR analysis in 1969 and created objective and numeric FHR analysis to achieve FHR score, which was determined every 5 min, and correlated neonatal Apgar score and umbilical cord blood pH, and precisely predicted neonatal well using and asphyxia using the regression equations to neonatal Apgar score and UApH

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Bed Bug Histamines are Substantial, Persistent in Infested Homes

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NC State post-doctoral researcher conducted a Raleigh-based study to compare histamine levels in homes with and without bed bug infestation. The researchers also evaluated the extent to which treatment and time affect those histamine levels.

“Histamine levels in bedbug-infested homes were at least 20 times higher than histamine levels in homes without bed bug.” And these levels didn’t decrease many three months after treating the infested homes with heat and insecticides.”

In humans, histamines are generally released as part of an immune response. They cause inflammation and help allow other immune system chemicals to fight a pathogen or to do cellular repair work. Histamines, though, can have deleterious effects in humans, including rashes when contacted with skin and respiratory problems when inhaled — think of the allergic reactions to certain foods, pollen, mould or other environmental conditions.”

More: https://www.scitechnol.com/clinical-dermatology-research-journal.php

Queries: dermatology@scitechnol.com

The coming of decade of gene therapy: A review of the past and path forward

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After three decades of hopes tempered by setbacks, gene therapy – the process of treating a disease by modifying a person’s DNA – is no longer the future of medicine, but is part of the present-day clinical treatment toolkit. A new article provides an in-depth and timely review of the key developments that have led to several successful gene therapy treatments for patients with serious medical conditions.

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Increasing Incidence of Rare Skin Cancer

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Merkel cell carcinoma (MCC) is rare, but it’s becoming less rare. Compared to melanoma, MCC is much more likely to be fatal, so it’s important for people to be aware of it. Because melanoma incidence has been increasing over the last few decades, researchers suspected that MCC incidence was increasing as well. After examining data from the National Cancer Institute’s SEER-18 registry, they found that it was increasing even more than they had anticipated.

From 2000-2013, the number of reported MCC cases increased 95 percent, compared to 57 percent for melanoma and 15 percent for other cancerous tumours. Based on current population trends, Dr. Nghiem and his team predict that MCC incidence will grow from nearly 2,500 cases in 2013 to more than 3,200 in 2025.

More: https://www.scitechnol.com/clinical-dermatology-research-journal.php

Queries: dermatology@scitechnol.com

Psoriasis Drugs also Reduces Aortic Vascular Inflammation

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Psoriasis is a chronic inflammatory disease that causes skin cells to multiply faster than normal resulting in raised, red patches covered by silvery scales. It occurs most commonly on the scalp, knees, and elbows but can appear anywhere on the body including the face, genitals, nails, and other places. In moderate to severe cases, it carries an increased risk of heart attack, stroke, and premature death, a finding established by Gelfand in a 2006 landmark study. The National Psoriasis Foundation estimates psoriasis affects about 7.5 million Americans.

Ustekinumab, sold under the name Stelara, is approved by the U.S. Food and Drug Administration to treat psoriasis, psoriatic arthritis, and Crohn’s Disease. Researchers wanted to know if the benefits of the drug go beyond clearing the skin.

“The type of inflammation we see in psoriasis is similar to what we see in atherosclerosis — a type of heart disease that involves the build-up of fats, cholesterol, and inflammatory cells in the artery walls,” Gelfand said. “Since ustekinumab blocks the specific pathways involved in both skin and cardiovascular inflammation, we wanted to test whether it can improve aortic vascular inflammation.”

More: https://www.scitechnol.com/clinical-dermatology-research-journal.php

Queries: dermatology@scitechnol.com