Genetics & Molecular Biology
After three decades of hopes tempered by setbacks, gene therapy – the process of treating a disease by modifying a person’s DNA – is no longer the future of medicine, but is part of the present-day clinical treatment toolkit. A new article provides an in-depth and timely review of the key developments that have led to several successful gene therapy treatments for patients with serious medical conditions.
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Merkel cell carcinoma (MCC) is rare, but it’s becoming less rare. Compared to melanoma, MCC is much more likely to be fatal, so it’s important for people to be aware of it. Because melanoma incidence has been increasing over the last few decades, researchers suspected that MCC incidence was increasing as well. After examining data from the National Cancer Institute’s SEER-18 registry, they found that it was increasing even more than they had anticipated.
From 2000-2013, the number of reported MCC cases increased 95 percent, compared to 57 percent for melanoma and 15 percent for other cancerous tumours. Based on current population trends, Dr. Nghiem and his team predict that MCC incidence will grow from nearly 2,500 cases in 2013 to more than 3,200 in 2025.
Psoriasis is a chronic inflammatory disease that causes skin cells to multiply faster than normal resulting in raised, red patches covered by silvery scales. It occurs most commonly on the scalp, knees, and elbows but can appear anywhere on the body including the face, genitals, nails, and other places. In moderate to severe cases, it carries an increased risk of heart attack, stroke, and premature death, a finding established by Gelfand in a 2006 landmark study. The National Psoriasis Foundation estimates psoriasis affects about 7.5 million Americans.
Ustekinumab, sold under the name Stelara, is approved by the U.S. Food and Drug Administration to treat psoriasis, psoriatic arthritis, and Crohn’s Disease. Researchers wanted to know if the benefits of the drug go beyond clearing the skin.
“The type of inflammation we see in psoriasis is similar to what we see in atherosclerosis — a type of heart disease that involves the build-up of fats, cholesterol, and inflammatory cells in the artery walls,” Gelfand said. “Since ustekinumab blocks the specific pathways involved in both skin and cardiovascular inflammation, we wanted to test whether it can improve aortic vascular inflammation.”
Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein to know more please visit https://www.scitechnol.com/abstract/a-networkbased-analysis-of-proteins-involved-in-hypoxia-stress-and-identification-of-leader-proteins-4982.html
Until a decade ago, scientists were not aware that bacteria had complex immune systems – ones that could keep up with the pace of evolution in viruses called phages that infect bacteria to know more please visit https://www.scitechnol.com/abstract/evaluation-of-tryptic-peptides-from-neisseria-meningitidis-outer-membrane-proteins-pora-and-porbrndigestion-peptides-6670.html
A Network-Based Analysis of Proteins Involved In Hypoxia Stress and Identification of Leader Proteins
Hypoxia arises in many pathophysiological conditions like hypertension, cancers, pre-natal birth and environmental conditions like high altitude, deep sea diving etc. The multivariate nature of this stress makes to it difficult to predict accurately susceptibility and adaptability to hypoxia. A large amount of expression data under hypoxic stress is generated and available in the public domain. However, there have been no systematic efforts to identify to know more please visit https://www.scitechnol.com/abstract/a-networkbased-analysis-of-proteins-involved-in-hypoxia-stress-and-identification-of-leader-proteins-4982.html
Purification and Characterization of Heparin Binding Proteins from Seminal Plasma of Cross- bred Cattle Bulls by Affinity Chromatography, SDS-PAGE and Mass Spectrometery
Heparin binding proteins (HBP) play a crucial role in the fertility of bovine semen. In this study HBPs purified from cross-bred cattle bull seminal plasma (SP) by sepharose-affinity chromatography were characterized by SDS-PAGE, and mass- spetrometery. Affinity chromatographic analysis indicated two peaks of unbound (non-HBP) and bound proteins (HBP). On average, seminal plasma of cross-bred bulls contained 39.36 ± 4.41% HBP with a peak area of 2.74 ± 0.82 cm2. Sixteen bands with molecular weights ranging from 14 kDa to 150 kDa could be separated by SDS-PAGE from seminal plasma of 11 bulls. SDS-PAGE analysis of the eluted HBP peaks identified 14 bands, with molecular weights ranging from 14 kDa to 150 kDa. However, variation in number of bands, separated in SP and SP-HBP was observed among the bulls. The matched peptides of 60; 40, 35; 31, 28; 25 and 20 kDa proteins with highest score (>61-67) were identified to have significant matching with the peptides of Platelet activatin factor AH; Clusterin preprotein; DNase1-L3 and TIMP-2, respectively. This study envisaged that four characterized SP-BHPs have important functions in reproduction. Please visit for more details http://www.scitechnol.com/peer-review/purification-and-characterization-of-heparin-binding-proteins-from-seminal-plasma-of-cross-bred-cattle-bulls-by-affinity-chromatog-FbYN.php?article_id=4983