Genetics & Molecular Biology

New nanotechnology application for difficult-to-treat cancers

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A new treatment combining shock waves with nanoparticles can successfully treat tumors that are difficult to target using conventional chemotherapy. This is the first time this combined therapy has been tested in live animals. The findings of this pre-clinical study could lead to the development of more effective therapies for treating life-threatening cancers in the future.


Cellular systems and biology breakthroughs

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There are various factors that can impact the health of a biological system, such as the cell cycle, differentiation of cells, carcinogenesis and biophysical factors. Changes in these areas can lead to altered transcription and translation of proteins, hence leading to differences in the proteome. It is evident that further advancement in the field of quantitative proteomics could lead to increased analysis and understanding of cellular systems and biology. This has the potential to be applied in a healthcare setting to improve patient health outcomes.To know more..

Significant goal for current proteomics researchers: Proteome of human plasma

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Another significant goal for current proteomics researchers is to characterize the proteome of human plasma. However, this is thought to the most challenging proteome within the human body as it includes various proteins, such as immunoglobulin, cytokines, hormones and haemostatic proteins. The proteome of human plasma holds insight about the physiological wellbeing of all other tissues within the body and is easily accessible for testing from individuals. Therefore, if the proteome can be established the information would be invaluable for medical purposes and could potentially be used as a diagnostic tool for a wide range of health conditions..To know more…

Effects of Acute Consumption of Garcinia kola on Hepatic Enzymes in Apparently Well Nigerian Youths

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Garcinia kola belongs to the Family Clusiaceae guttiferae and contains a complex mixture of biflavonoids, prenylated benzophenones and xanthone1. Its seeds, popularly called ‘Bitter Kola’, form an integral part of the herbal preparations used in traditional African medicine. A lot of studies have been done in animals to look at the effects of Garcinia kola on their organs, very few have been done in human beings. This study was done to look at the effect of acute consumption of Garcinia kola on hepatic enzymes in apparently well Nigerian youths. The response of aspartat… know more..

PROK2 and PNCK – Novel Proteins Present in Follicular Fluid of Mature and Immature Human Oocytes: Preliminary Study

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Analysis of follicular fluid (FF), granulosa (GC) and cumulus cells (CC) gene expression can unravel the physiology of oocyte maturation. In our previous study, a meta-analysis of microarray results showed that prokineticin 2 (PROK2) and pregnancy up-regulated non-ubiquitis CaMkinase (PNCK) genes are differentially expressed between GC and CC. Follicular fluid represents an important medium for oocyte maturation. It contains mediators of folliculogenesis and their identification would help us better understand the process of oocyte maturation.For more:–novel-proteins-present-in-follicular-fluid-of-mature-and-immature-human-oocytes-preliminary-study-aIWK.php?article_id=5811 Contact us: (or)

An Overview of Proteomics Techniques and its Application as a Tool in Biomarker and Drug Discovery

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Introduction: Proteomics technology is extensively used to identify the underlying molecular mechanisms of various diseases. Emergent technologies in proteomics have been used in the biomarker and drug discovery process. Proper use of this technology can enable the understanding of mechanism of drug action; efficacy and toxicity, there by facilitating effective translation of the drug from bench to bedside.

Areas covered: The major techniques used in proteomics technology with an application in drug discovery process are discussed. An overview on different kinds of proteomic approaches and their application in various fields of biomarker discovery as well as drug development process has also been presented.

Biotinidase Deficiency Presenting as Hyperventilation Syndrome

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Biotinidase is responsible for recycling the vitamin, biotin, and making the free biotin available to activate the biotin-dependent carboxylases, including pyruvate carboxylase, which is involved in mitochondrial energy metabolism. Individuals with untreated biotinidase deficiency usually exhibit lethargy, hypotonia, ataxia, cutaneous abnormalities, vision and hearing impairment and developmental delay.
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