Fast determination of bronopol in cosmetic products by vortex-assisted emulsification extraction combined with liquid chromatography

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Bronopol (2-bromo-2-nitropropane-1,3-diol) is an effective preservative employed in cosmetic formulations. However, under specific conditions, bronopol can decompose releasing low levels of formaldehyde and nitrites. These last compounds can react with any secondary amines or amides to produce significant levels of carcinogenic nitrosamines. The production of nitrosamines in cosmetic products has to be avoided. For this reason, although the use of bronopol is authorized in the current European Regulation, the maximum allowed concentration of bronopol in cosmetic products is 0.1%. Nevertheless, there is still no official method of analysis for the determination of this compound. The aim of this work is to propose a fast and simple analytical method to determine bronopol in cosmetic products. The proposed method is based on a vortex-assisted emulsification extraction, as one-step solution extraction process to prepare cosmetic samples, followed by liquid chromatography with spectrophotometric detection at 250 nm.


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