Incidence of osteoporosis is higher in women than in men . The estimated number of osteoporotic patients aged 40 or over in Japan is 3,000,000 men and 9,800,000 women. Because a high peak bone mass in early adulthood is an important protective factor against osteoporotic fractures in later life, and peak bone mass occurs in approximately in the third or fourth decade of life , maximizing peak bone mass before menopause may be important in preventing osteoporosis in premenopausal women.
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