Effects of Periodontitis on the Colon Microbiome

Posted on Updated on

Synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE-/-mice. The gut microbiome plays a vital role in intestinal motility, however it is unclear whether oral polybacterial DNA is present in colon and how it alters the microbiome and NO synthesis in this mice animal model. The goal of this study was to determine whether oral pathogens are found in the colon and to investigate how these pathogens modulate the microbiome of the colon. Colon specimens were obtained from 16 weeks polymicrobial-infected and healthy mice. Microbial DNA from colon specimens were isolated and analyzed by use of 454 pyrosequencing of 16S RNA genes.

Read more at https://bit.ly/2jHEH9t

Submit manuscript at dentalhealth@scitechnol.com


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s