Sleep Disordered Breathing in Prader-Willi Syndrome: A Review

Posted on

PWS is a rare genetic disorder characterized by cognitive impairment, hypogonadism, morbid obesity due to hyperphagia and lack of satiety, and hypothalamic dysfunction. PWS is closely associated with SDB in many forms.GH therapy was approved in 2000 for treatment of PWS and has been successful in promoting linear growth and improving muscular trophism and tone, with a consequent improvement in strength, physical activity and cardiorespiratory function as well as SDB. However it is not without its complications, in particular sudden deaths. Patients should be managed in the multidisciplinary team with regular polysomnogram especially in the first few weeks following initiation of the treatment. There are other conservative options that can be considered for persistence of SDB despite GH as well as surgical options.

For more information visit:
Contact us:


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s