RA is the most mutual prolonged systemic autoimmune disease, with a difficult dominance in women, proposing female hormonal factors play a character in the growth of the disease. However, many arguments still exist. The object of this analysis was to consider data from modern enquiry regarding female hormonal factors and their suggestion with RA disease enlargement. The study of female hormonal factors is stimulating because serum levels may contrast during a woman’s lifetime and cooperate with countless environmental, immunological, genetic and endocrine factors persuading the enlargement of autoimmunity. As some female hormonal factors may be possibly changeable, thoughtful their influence on RA enlargement is clinically significant and may effect in specific protective mediations in high-risk residents.