Researchers have synthesized copper-containing bio glass nanoparticles that improve bone repair by providing the right conditions for new growth while suppressing bacterial infections. Conventional treatments for bone defects arising from conditions such as osteoporosis or trauma like fractures can be ineffective, especially if there is infection. But mesoporous bioactive glass (MBG) nanoparticles, developed by Chiara Vitale-Brovarone, Sonia Fiorilli, and colleagues at Politecnico di Torino, Livia Visai at University of Pavia, and Maria Vallet-Regí at Universidad Complutense de Madrid, take a multifunctional role.
The copper-containing MBGs simultaneously promote new bone growth (osteostimulation), have an antibacterial effect, and can induce the formation of blood vessels (proangiogenic).
The researchers used a one-pot, ultrasound-assisted sol-gel method, which relies on a template agent, to assemble a regular Nano porous structure in a bioactive glass.
“This is the first study using the template sol-gel method to produce MBG nanoparticles containing copper ions,” says Vitale-Brovarone.
The MBG nanoparticles can be coated with stimuli responsive agents and delivered directly to the site of damage or infection. Alternatively, nanoparticles could be dispersed in an organic matrix and implanted into the body to produce collagen-based composites that induce bone remodeling. The researchers believe the nanoparticle offer a promising approach to the prevention of infection and stimulation of bone regeneration. Different ions could also be introduced into the MBG mixture to improve osteostimulation and reduce the activity of osteoclasts related to osteoporosis.