Accurate diagnosis of infection with Mycobacterium tuberculosis is important in low prevalence populations, such as healthcare workers, subjected to serial- or mass entry screen testing. There is no gold standard laboratory test for detecting latent tuberculosis infections (LTBI). Interferon-γ (IFN-γ) release assays (IGRAs) are in vitro immunodiagnostic tests that measure the effecter T cell– mediated IFN-γ response to synthetic Mycobacterium tuberculosis– specific polypeptides. When compared to the tuberculosis skin test (TST) IGRAS, including the QuantiFERON-TB Gold In-Tube (QFTGIT, QIAGEN GmbH, GER), have been shown to reduce the number of false positive LTBI diagnoses and thus substantially lower followup costs.
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