Mitochondrial Inhibitors and Alteration in Bioenergetics-the Dose makes the Poison

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Hydrogen sulfide and Cyanide are said to be inhibitors of mitochondria, known for their poisonous effect on mitochondria. As it has to ability to interfere with the cellular respiration resulting in decreased mitochondrial bioenergetics which leads to cellular failure. While these inhibitors act as a poison, they are also found to be having  potential protective aspect , to prevent the ischemic-reperfusion injuries which are related to the reactive oxygen species(ROS) and similar to “hibernation “ or “suspended animation” where there is an ability to decrease metabolic demands.

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