Exposure to Exogenous Female Sex Hormones is Associated with Increased Risk of Orbito-Cranial Meningioma in Females: A Case-Control Study
This study aimed to investigate the association of exposure to exogenous female sex hormones with orbito-cranial meningioma among females.This was a case-control study of 115 women (40 orbitocranial meningioma cases and 75 healthy controls). All cases were confirmed by Multi-sliced head CT scan and histopathological examination following the surgical procedure. Age-matched control (2 years) were meningioma-free, confirmed by clinical examination and head CT-scan. Detailed history of previous hormonal contraception, menstrual cycle, parity history and other demographic data were obtained by interview. The association of hormonal contraception with incident meningioma was estimated using logistic regression, adjusted for education level, age of menarche, length of menstrual cycle and number of parity.