Acute Cytolytic Hepatitis Probably due to Lercadinipine

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An 84-y. man was treated by fluindione and verapamil. The latter has been changed for lercanidipine and amiodarone. At day 4, started epigatric ache and asthenia and, at day 14, dark urines. Lercanidipine but not amiodarone, has been stopped at day 16. Blood tests disclosed GPTx10. US and virus tests were negative. Liver tests reverted to normal within 2 months.Responsibility of lercanidipine seems probable.

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