Synthesis, Antiproliferative Activity of Nitrile Containing Pyranes and 1,2,5,6,7,8-Hexahydroquinoline-3,3,4,4-Tetraсarbonitriles

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lMethyl 6-Amino-3-acyl-4-aryl-5-cyano-4H-pyran-2-carboxylates, 9-aryl-12-imino-10,11 dioxatricyclo-[5.3.2.01,6]-dodecan-7,8,8- tricarbonitriles, 2-R-1,2,5,6,7,8-hexahydroquinoline-3,3,4,4- tetra?arbonitriles were synthesized. The antiproliferative activity of obtained compounds was investigated. At a concentration of 10 μM test substances activity higher than that of the drug busulfan and cisplatin showed a compounds containing in its composition fragment of ethyl 1,1,2,2-tetracarbonitrile – 2-R-1,2,5,6,7,8- hexahydroquinoline-3,3,4,4-tetra?arbonitriles….to read more: http://www.scitechnol.com/peer-review/synthesis-antiproliferative-activity-of-nitrile-containing-pyranes-and-125678hexahydroquinoline3344tetraarbonitriles-T97H.php?article_id=5504

To know more: https://www.scitechnol.com/pharmaceutical-sciences-emerging-drugs.php

Submit Manuscript: editor.jpsed@scitechnol.com or editor.jpsed@scitechnol.org

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