Cell Adhesions and Communication is the coupling of a cell to a surface or substrate, for example, an extracellular grid of another cell. Cell Adhesion and Communication happens from the activity of proteins, called cell bond particles, or at times adhesins. Adhesion of like cells is a primary feature of the architecture of many tissues. A sheet of absorptive epithelial cells, for instance, forms the lining of the small intestine, and sheets of hepatocytes two cells thick make up much of the liver. A number of cell-surface proteins (the CAMs), mediate such homophilic (like-binds-like) adhesion between cells of a single type and heterophilic adhesion between cells of different types. Most CAMs are uniformly distributed along the regions of plasma membranes that contact other cells, and the cytosol-facing domains of these proteins are usually connected to elements of the cytoskeleton.
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