Postnatal Development and Maturation of the Vestibular Organ in Dominant-Negative Connexin 26 Transgenic Mouse

Posted on

Immunohistochemical studies have revealed that connexin 26 (Cx26) exists not only in the cochlea but also in the vestibular organs. K+ cycling involving gap junction protein Cx26 in the vestibular labyrinth, which is similar to that in the cochlea, is thought to play a fundamental role in endolymph homeostasis and sensory transduction. The gross structure of the inner ear in non-transgenic and transgenic mice revealed no hydrops, no defects, no degeneration in either the cochlea or the vestibule throughout the postnatal period. Light microscopic observations in the sensory epithelium revealed normally developed and matured utricula macula, saccular macula, and ampulla in the transgenic mice, which were very similar to those of the nontransgenic mouse. The present study clearly demonstrated that postnatal development and maturation in the vestibular organ were morphologically and functionally completed in Cx26 transgenic mice.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s