The structural efficacy of TNF alpha in spine in spondylarthrities (SpA) has been reported in several studies with prolonged follow. None of these studies did however assessed their effects in a particulary severe population of SpA with hip disease. A comparative multicenter cohort study has included two groups of SpA patients with Group 1: Patients under TNF inhibitors and group 2: TNF alpha inhibitors naive patients under conventional treatment. Clinical, biological and radiological (using mSASSS score and BASRI spine) evaluations were performed before applying anti TNF (T0), after 2 years (T2) and after a period of treatment with n ≥3 (Tn) and compared to group 2.
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