Biochemical and Histopathological Alterations as Forensic Markers of Asphyxiated Rats and the Modifying Effects of Salbutamol and/or Digoxin Pretreatment

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Asphyxia is mainly induced by interference with respiration, or lack of oxygen in respired air as in entrapment suffocation that may occur in animals or human. In a study where 24 male albino rats were assigned into four equal groups: G1 (control negative); G2 (exposed to asphyxia); G3 (asphyxiated pretreated rats with salbutamol); G4 (asphyxiated pretreated rats with digoxin). The results revealed no change in the time intervals from onset of suffocation till coma (G2, G3 and G4). Also, all external and internal classical signs of asphyxia appeared on animals of different asphyxiated groups. Moreover, Asphyxiated rats (G2) showed significant (P ≤ 0.05) increase in serum ALT, AST, urea and uric acid and insignificant increase in serum direct and total bilirubin levels but significant reductions of serum glucose, total protein and albumin levels compared to control ones. Pretreatment with salbutamol or digoxin induced insignificant reverse effects on mentioned parameters than those of asphyxiated rats except in serum ALT and AST activities and serum urea level of digoxin pretreated rats.
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