Spinal Stargazin-Mediated Cross-Talk of AMPA/NMDA Receptors in Chronic Pain

Posted on

Chronic pain resulting from a variety of health conditions is the primary reason people seek medical care; yet current therapies either are inadequate or cause intolerable side effects [1-8]. Understanding cellular and molecular processes that lead to the initiation and maintenance of chronic pain will provide substantial promise for the development of more effective and specific pain therapies. Chronic pain is an expression of neuronal plasticity. One component of the plasticity is that the afferent input generated by injury and intense noxious stimuli triggers an increased excitability of nociceptive neurons in the spinal cord. Glutamate is the principal excitatory amino acid neurotransmitter within the mammalian nervous system.

Know more at http://www.scitechnol.com/analgesia-resuscitation-current-research.php


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s