Tau protein present in brain under normal functioning condition contributes to the healthy functioning of neurons but when collects into toxic tangles is believed to cause damages in brain resulting in Alzheimer‘s disease.
However the researchers at Washington University School of Medicine in St. Louis have found a drug known as antisense oligonucleotide that can lower tau levels and prevent some neurological damage. This drug targets the tau proteins before getting tangled and prevents it from causing further damage.
It worked in the following manner :
Genes in the DNA are copied into RNA, a messenger molecule that carries the instructions for building a protein. Antisense oligonucleotides bind to the messenger RNA and target it for destruction before the protein can be built. Such oligonucleotides can be designed to target the RNA for almost any protein.
It is not yet administered in humans but it has raised a hope in curing diseases like Alzheimer’s disease and other neuro generative diseases.
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