Micro RNA-142-5p Profile as a Predictor of Tumor Markers Regulation in Different Histological Grades of Human Breast Carcinoma

Posted on Updated on

Micro RNA (miRNA) is one of the kinds in non-coding RNA class that regulates gene expression by translational repression, mRNA cleavage, mRNA disruption initiated by miRNA-guided rapid de-adenylation. Up- and/or down-regulated expression study of the miRNA is a good approach to study their function in cancer pathogenesis. In our previous study we understood the down regulation of polycomb gene BMI1 and its correlation with histochemical markers like ER, PR and Her2 in different histological grades of breast tumors. To derive on the identification of regulatory factor accountable for this gene regulation pattern, we tried to identify miRNA that could sway on the gene regulation with the consecutive tumor grades. To adequate this perspective we identified miR-142-5p as a regulating marker for the proliferation of human ductal invasive breast carcinoma using microarray hybridization and attempted to demonstrate the expression profile of miR-142-5p in various histological grades of human breast carcinoma using Real time-PCR amplification. The up regulation of miR-142-5p in histological Grades I, II and III predicted variation with the hormone receptor status…..to read more: http://www.scitechnol.com/peer-review/micro-rna1425p-profile-as-a-predictor-of-tumor-markers-regulation-in-differenthistological-grades-of-human-breast-carcinoma-bQJF.php?article_id=4905

Contact us by E-mail: editor.jceog@scitechnol.com and oncology@jscitech.com

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s